Masterarbeit, Heidi Lischer

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====== FDist2 (datacal)======
**[[http://www.rubic.rdg.ac.uk/~mab/software.html|FDist2]]**\\
{{readme_fdist2.pdf|documentation}}

\\
A program to detect loci that might be under selection in samples from structured populations.

===== Program information =====
  * Linux
  * DOS



===== Data type handled =====
  * Microsat
  * DNA
  * Standard (multi-allelic marker)



===== Input Files =====
==== fdist2 - this is the simulation program: ====
  * consists of 6 lines:
    * Total number of demes (100 max)
    * No of populations sampled (must be less than or equal to total number of demes)
    * Expected Fst for infinite allele, infinite island model
    * Sample size (assumed the same in all populations) 
    * Indicator - 1 for stepwise mutations; 0 for infinite alleles
    * No of realizations (loci) 

=== example ===
<code>
100
15
0.17
50
0
20000
</code>



==== datacal ====
  * 1/0 indicator: alleles by rows in data matrix (1), or pops by rows (0).
  * No of pops
  * no of loci
  * no of alleles at locus 1
  * matrix of data at locus 1 either with each row corresponding to the same allele or to the same population 
  * no of alleles at locus 2
  * matrix...
  * etc.
  * The data matrices can contain populations for which a locus was not genotyped, these should be indicated by zero entries 

=== example ===
<code>
0
15
2

3
4 76 0 
45 115 0 
109 11 0 
120 0 0 
0 0 0 
0 0 0 
0 0 0 
0 0 0 
13 67 0 
47 65 0 
0 0 0 
0 0 0 
0 74 6 
7 64 9 
26 74 0 

3
4 23 53 
0 38 122 
0 72 48 
0 57 63 
0 0 0 
0 0 0 
0 0 0 
0 0 0 
0 0 80 
0 0 112 
0 0 0 
0 0 0 
0 0 80 
0 8 72 
0 16 84 
</code>







===== How to cite =====
  * Beaumont and Nichols. Evaluating loci for use in the genetic analysis of population structure. (1996) Proc Roy. Soc. Lond. B. 263: 1619-1626 
  * Flint et al. Minisatellite mutational processes reduce F-st estimates. (1999) Human Genet 105: 567-576