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hickory [2007/12/12 11:26] – created heidihickory [2008/07/22 13:31] (current) – external edit 127.0.0.1
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 ====== HICKORY ====== ====== HICKORY ======
 +{{hickory2.png?400}}\\
 +**[[http://darwin.eeb.uconn.edu/hickory/hickory.html|HICKORY]]**\\
 +[[http://darwin.eeb.uconn.edu/hickory/documentation/Hickory.pdf|documentation]]
 +
 +\\
 +version 1.1\\
 +Software for analysis of geographic structure in genetic data. The software implements the Bayesian method described in Holsinger (1999) for estimating F-statistics co-dominant marker data and the method described in Holsinger et al. (2002) for estimating F-statistics from dominant marker data. It also includes routines to allow posterior comparisons as described in Holsinger and Wallace (2004).
  
 ===== Program information ===== ===== Program information =====
 +  * Windows
 +  * Linux
 +
 +
 ===== Data type handled ===== ===== Data type handled =====
 +  * dominant markers
 +  * co-dominant markers
 +  * AFLP (amplified fragment length polymorphism)
 +  * RAPD (random amplified polymorphic DNA)
 +  * multi-allelic markers
 +
 +
 +
 +
 +
 +
 ===== Input Files ===== ===== Input Files =====
 +files in [[NEXUS]] format
 +  * need only an **alleles block:** <code>
 +#nexus
 +begin alleles; [comments are surrounded by square brackets]
 + dimensions newpops npops=2 nloci=3;
 + format labels missing=? separator=/;
 + locusallelelabels
 +  1 ’pgi 1’,
 +  2 ’pgi 2’,
 +  3 adh;
 + matrix
 +  Embudo:
 +   indiv_1 A/A 100/110 slow/fast
 +   indiv_2 A/A 75 / 90 slow/slow
 +   indiv_3 A/a 75/100 fast/slow
 +   indiv_4 A/A 100/100 fast/fast,
 +  Black_Mesa:
 +   1 a/a 110/100 fast/slow
 +   2 a/A 75/100 slow/slow
 +   3 a/a 100/100 fast/fast
 +  ;
 +end;
 +</code>
 +    * **dimensions command:** 
 +      * nloci: number of loci scored
 +      * npops: number of populations scored
 +    * **format command:**
 +      * missing: character to be used for missing data (missing diploid genotype would thus be specified as ?/?)
 +    * **locusallelelabels command:**
 +      * optional (loci will simply be numbered)
 +      * comma-separated list of locus number and locus name pairs
 +    * **matrix command:**
 +      * The genotype for a diploid locus at a co-dominant locus takes the form A/a
 +      * forward slash (/) symbol serves as a separator symbol, making it clear which pairs of alleles belong to each locus
 +      * If the loci represent dominant genetic markers, do not use the slash and specify only one allele for each locus
 +      * phenotype for a dominant locus (dominant marker): 
 +        * keyword ''dominant''
 +        * dominant phenotype is scored as ''1'' (or ''+'') or ''0'' (''−'') (default)
 +        * Hickory accepts the following alternatives: <code>
 +dominant;                 -> default         
 +dominant all:1;           -> default
 +dominant all:0;           -> dominant phenotype at all loci scored as 0 (recessive = 1) 
 +dominant 1,2,3:1 4,5:0;   -> dominant phenotype at first 3 loci scored as 1 and at last 2 loci scored as 0
 +dominant 1-3:1 4-5:0;     -> dominant phenotype at first 3 loci scored as 1 and at last 2 loci scored as 0
 +</code>
 +
 +\\
 +  * the **hickory block** is optional:
 +    * you can set parameters governing the MCMC sampler
 +
 +
 ===== How to cite ===== ===== How to cite =====
 +  * Holsinger, K. E. 1999. Analysis of genetic diversity in geographically structured populations: a Bayesian perspective. Hereditas 130:245-255.
 +  * Holsinger, K. E., P. O. Lewis, and D. K. Dey. 2002. A Bayesian approach to inferring population structure from dominant markers. Molecular Ecology 11:1157-1164.
 +  * Holsinger, K. E., and L. E. Wallace. 2004. Bayesian approaches for the analysis of population structure: an example from Platanthera leucophaea (Orchidaceae). Molecular Ecology 13:887-894.
 +  * Song, S., D. K. Dey, and K. E. Holsinger. 2006. Differentiation among populations with migration, mutation, and drift: implications for genetic inference. Evolution 60:1-12.
hickory.1197455208.txt.gz · Last modified: 2008/07/22 13:30 (external edit)